Sweet grass is treasured by the Sioux, Cherokee, Blackfoot, Lakota and other native American peoples and associate the scented grass with the compassionate creation goddess Wohpe.

Sweetgrass oil is often used in spiritual practices to purify spaces and attract positive energy. Its sweet, vanilla-like aroma is believed to create a sacred atmosphere and encourage feelings of peace and harmony. It is sometimes used to cleanse objects, bless homes, and promote healing.